XIAP 抗体 (AA 1-268)
Quick Overview for XIAP 抗体 (AA 1-268) (ABIN7193408)
抗原
See all XIAP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-268
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原理
- XIAP Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human XIAP (AA: 1-268) expressed in E. Coli.
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亚型
- IgG2b
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
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别名
- XIAP
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背景
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This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
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分子量
- 56.7 kDa
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基因ID
- 331
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UniProt
- P98170
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
抗原
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