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DNMT3B 抗体 (N-Term)

DNMT3B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7184447
发货至: 中国
  • 抗原 See all DNMT3B 抗体
    DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
    抗原表位
    • 18
    • 16
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    • 3
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    N-Term
    适用
    • 82
    • 57
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    • 3
    • 2
    • 2
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    宿主
    • 79
    • 5
    • 2
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    克隆类型
    • 72
    • 15
    多克隆
    标记
    • 37
    • 5
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    This DNMT3B antibody is un-conjugated
    应用范围
    • 75
    • 37
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    交叉反应
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    免疫原
    Synthesized peptide derived from N-terminal of Human DNMT3B.
    亚型
    IgG
    Top Product
    Discover our top product DNMT3B Primary Antibody
  • 应用备注
    WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
    别名
    DNMT3B (DNMT3B 产品)
    别名
    DNMT3B antibody, LOC100218113 antibody, ICF antibody, ICF1 antibody, M.HsaIIIB antibody, MmuIIIB antibody, cb91 antibody, dnmt3bl antibody, dnmt7 antibody, sb:cb91 antibody, wu:fb16h07 antibody, DNA methyltransferase 3 beta antibody, DNA methyltransferase 3B antibody, DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a antibody, DNMT3B antibody, Dnmt3b antibody, dnmt3b antibody, dnmt3ba antibody
    背景

    Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

    Deloukas P., Nature 414:865-871(2001).
    Li H., J. Biol. Chem. 281:19489-19500(2006).
    Wijmenga C., Hum. Mutat. 16:509-517(2000).

    Aliases: Cytosine 5methyltransferase 3B antibody, DNA antibody, DNA (cytosine 5) methyltransferase 3 beta antibody, DNA (cytosine 5)-methyltransferase 3B antibody, DNA (cytosine-5)-methyltransferase 3B antibody, DNA methyltransferase HsaIIIB antibody, DNA MTase HsaIIIB antibody, DNM3B_HUMAN antibody, Dnmt3b antibody, EC 2.1.1.37 antibody, ICF antibody, ICF1 antibody, M.HsaIIIB antibody, MGC124407 antibody, RP23-89H14.3 antibody

    UniProt
    Q9UBC3
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