IFI16 抗体
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北京 101111
Quick Overview for IFI16 抗体 (ABIN7183658)
抗原
See all IFI16 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- IFI16 Antibody
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from internal of Human IFI16.
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亚型
- IgG
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anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 465-671) antibody
IFI16 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) antibodyIFI16 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-729) antibodyIFI16 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-729) antibodyIFI16 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B4 unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 1-729) antibodyIFI16 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (C-Term) antibodyIFI16 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 1-729) antibodyIFI16 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 201-350) antibodyIFI16 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-729) antibodyIFI16 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-730) antibodyIFI16 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))
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别名
- IFI16
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背景
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Background: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication.
Trapani J.A., Immunogenetics 36:369-376(1992).
Trapani J.A., Immunogenetics 40:415-424(1994).
Jiang C., Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.Aliases: IFI16 antibody, IFNGIP1 antibody, Gamma-interferon-inducible protein 16 antibody, Ifi-16 antibody, Interferon-inducible myeloid differentiation transcriptional activator antibody
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UniProt
- Q16666
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途径
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome
抗原
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