Estrogen Receptor alpha 抗体 (Tyr537)
Our Local Distributor
北京 101111
Quick Overview for Estrogen Receptor alpha 抗体 (Tyr537) (ABIN7180008)
抗原
See all Estrogen Receptor alpha (ESR1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Tyr537
-
原理
- ESR1 (Ab-537) Antibody
-
交叉反应
- 小鼠
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Synthesized non-phosphopeptide derived from Human Estrogen Receptor-alpha around the phosphorylation site of tyrosine 537 (P-L-Y(p)-D-L).
-
亚型
- IgG
-
-
anti-Estrogen Receptor 1 (ESR1) antibody
ESR1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal ESR1-1904 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 129-312) antibodyESR1 适用: 人 IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal ESR1-3557 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibodyESR1 适用: 人, 大鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 6A6E8 unconjugated
anti-Estrogen Receptor 1 (ESR1) (pSer167) antibodyESR1 适用: 人, 大鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (C-Term) antibodyESR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibodyESR1 适用: 人 WB, IHC, FACS, StM 宿主: 小鼠 Monoclonal ER506 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 246-273) antibodyESR1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB33807 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 246-273) antibodyESR1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 331-360) antibodyESR1 适用: 人, 大鼠 WB, ELISA, FACS, IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (pSer118) antibodyESR1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
-
别名
- ESR1
-
背景
-
Background: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1.Sehime Temel, Endocrinology, Oct 2002, 143: 3974. Xin-Tian Zhang, AACR Meeting Abstracts, Apr 2005, 2005: 302. Suwit J. Somponpun, Am J Physiol Regulatory Integrative Comp Physiol, Sep 2004, 287: R661 - R669.
Aliases: 7*/654 isoform antibody, 7*/819 2 isoform antibody, 7*/822 isoform antibody, 8*/901 isoform antibody, 8*/941 isoform antibody, DKFZp686N23123 antibody, ER alpha antibody, ER antibody, ER-alpha antibody, Era antibody, ESR antibody, ESR1 antibody, ESR1_HUMAN antibody, ESRA antibody, Estradiol receptor antibody, Estrogen nuclear receptor alpha antibody, Estrogen receptor 1 antibody, Estrogen receptor alpha 3*,4,5,6,7*/822 isoform antibody, Estrogen receptor alpha antibody, Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform antibody, Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform antibody, Estrogen receptor alpha delta 4 +49 isoform antibody, Estrogen receptor alpha delta 4*,5,6,7*/654 isoform antibody, Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform antibody, Estrogen receptor alpha E1 E2 1 2 antibody, Estrogen receptor alpha E1 N2 E2 1 2 antibody, Estrogen receptor antibody, ESTRR antibody, NR3A1 antibody, Nuclear receptor subfamily 3 group A member 1 antibody
-
UniProt
- P03372
-
途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
抗原
-
