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SUV39H1 抗体 (AA 211-310)

This 兔 多克隆 anti-SUV39H1 antibody specifically detects SUV39H1 in ELISA, IF (cc), IF (p), IHC (p) 和 IHC (fro). The antibody is reactive with 人 samples.
产品编号 ABIN713561
发货至: 中国
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Quick Overview for SUV39H1 抗体 (AA 211-310) (ABIN713561)

抗原

See all SUV39H1 抗体
SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

适用

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宿主

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克隆类型

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多克隆

标记

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This SUV39H1 antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 211-310

    预测反应

    Human,Mouse,Rat,Dog,Cow,Pig

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Histone-lysine N-methyltransferase SUV39H1

    亚型

    IgG
  • 应用备注

    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

    别名

    SUV39H1

    背景

    Synonyms: H3 K9 HMTase, H3 K9 HMTase1, H3-K9-HMTase 1, Histone H3 K9 methylation, Histone H3 Lys 9 methylation, Histone H3-K9 methyltransferase 1, Histone H3-K9 methyltransferase1, Histone lysine N methyltransferase H3 lysine 9 specic 1, Histone lysine N methyltransferase, H3 lysine 9 specic 1, Histone-lysine N-methyltransferase SUV39H1, KMT1 A, Lysine N methyltransferase 1A, Lysine N-methyltransferase 1A, MG44, mIS6, Position-effect variegation 3-9 homolog, Suvar3 9 homolog 1, Suvar3-9 homolog 1, Suppressor of variegation 3 9 homolog 1 Drosophila, Suppressor of variegation 3-9 homolog 1, SUV39 H1, SUV39H, SUV39H1, SUV91_HUMAN.

    Background: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.

    基因ID

    6839
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