KEAP1 抗体 (AA 1-624)
Quick Overview for KEAP1 抗体 (AA 1-624) (ABIN7177369)
抗原
See all KEAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-624
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Mouse Kelch-like ECH-associated protein 1 protein (1-624AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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别名
- Keap1
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背景
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Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
Aliases: Keap1 antibody, Inrf2 antibody, Kiaa0132Kelch-like ECH-associated protein 1 antibody, Cytosolic inhibitor of Nrf2 antibody, INrf2 antibody
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UniProt
- Q9Z2X8
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途径
- Maintenance of Protein Location
抗原
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