MMP2 抗体 (AA 412-662)
Quick Overview for MMP2 抗体 (AA 412-662) (ABIN7176884)
抗原
See all MMP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 412-662
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交叉反应
- 人, 小鼠
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Mouse 72 kDa type IV collagenase protein (412-662AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:1000-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MMP2 (Matrix Metalloproteinase 2 (MMP2))
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别名
- Mmp2
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背景
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Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).By similarity PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).By similarity Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
Aliases: Mmp2 antibody, 72 kDa type IV collagenase antibody, EC 3.4.24.24 antibody, 72 kDa gelatinase antibody, Gelatinase A antibody, Matrix metalloproteinase-2 antibody, MMP-2) [Cleaved into: PEX] antibody
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UniProt
- P33434
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途径
- Activation of Innate immune Response
抗原
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