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MMP2 抗体 (AA 412-662)

This anti-MMP2 antibody is a 兔 多克隆 antibody detecting MMP2 in WB 和 ELISA. Suitable for 小鼠.
产品编号 ABIN7176884
发货至: 中国

Quick Overview for MMP2 抗体 (AA 412-662) (ABIN7176884)

抗原

See all MMP2 抗体
MMP2 (Matrix Metalloproteinase 2 (MMP2))

适用

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小鼠

宿主

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克隆类型

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多克隆

标记

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This MMP2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
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    AA 412-662

    交叉反应

    人, 小鼠

    纯化方法

    Antigen Affinity Purified

    免疫原

    Recombinant Mouse 72 kDa type IV collagenase protein (412-662AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:1000-1:5000,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    MMP2 (Matrix Metalloproteinase 2 (MMP2))

    别名

    Mmp2

    背景

    Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).By similarity PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels (By similarity).By similarity Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

    Aliases: Mmp2 antibody, 72 kDa type IV collagenase antibody, EC 3.4.24.24 antibody, 72 kDa gelatinase antibody, Gelatinase A antibody, Matrix metalloproteinase-2 antibody, MMP-2) [Cleaved into: PEX] antibody

    UniProt

    P33434

    途径

    Activation of Innate immune Response
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