XAF1 抗体 (AA 172-259) (HRP)
Quick Overview for XAF1 抗体 (AA 172-259) (HRP) (ABIN7175924)
抗原
See all XAF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 172-259
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human XIAP-associated factor 1 protein (172-259AA)
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亚型
- IgG
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anti-XiAP Associated Factor 1 (XAF1) (AA 151-250) antibody
XAF1 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 1-301) antibodyXAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 172-259) antibodyXAF1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 235-269), (C-Term) antibodyXAF1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB49525 unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 1-301) antibodyXAF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (C-Term) antibodyXAF1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 202-301) antibodyXAF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E5 unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 201-218) antibodyXAF1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 107-156) antibodyXAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 215-264) antibodyXAF1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- XAF1 (XiAP Associated Factor 1 (XAF1))
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别名
- XAF1
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背景
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Background: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Aliases: BIRC 4 binding protein antibody, BIRC4 binding protein antibody, BIRC4-binding protein antibody, BIRC4BP antibody, HSXIAPAF 1 antibody, HSXIAPAF1 antibody, XAF 1 antibody, XAF1 antibody, XAF1_HUMAN antibody, XIAP associated factor 1 antibody, XIAP-associated factor 1 antibody, XIAPAF1 antibody
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UniProt
- Q6GPH4
抗原
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