FAM105B 抗体 (AA 1-287)
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北京 101111
Quick Overview for FAM105B 抗体 (AA 1-287) (ABIN7174397)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-287
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原理
- OTULIN Antibody
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Ubiquitin thioesterase otulin protein (1-287AA)
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亚型
- IgG
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anti-Family with Sequence Similarity 105, Member B (FAM105B) (AA 99-128) antibody
FAM105B 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB27178 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
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别名
- OTULIN
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背景
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Background: Deubiquitinase that specifically removes linear (\'Met-1\'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). Required for homeostasis of the LUBAC complex by restricting autoubiquination of the LUBAC complex subunit RNF31 (PubMed:24726323). Some results have suggested that OTULIN function is restricted to homeostasis of the LUBAC complex, because it is not stably associated with TNF or NOD2 receptor signaling complexes (RSCs) (PubMed:26670046). However, further report have shown that it plays active roles in receptor signaling (PubMed:26997266, PubMed:27523608). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a key role in innate immune response by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334).
Aliases: AIPDS antibody, Deubiquitinating enzyme otulin antibody, F105B_HUMAN antibody, Fam105b antibody, Family with sequence similarity 105, member B antibody, FLJ34884 antibody, GUM antibody, OTU deubiquitinase with linear linkage specificity antibody, OTULIN antibody, Protein FAM105B antibody, Ubiquitin thioesterase Gumby antibody
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UniProt
- Q96BN8
抗原
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