FAM105B 抗体 (AA 75-125)
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北京 101111
Quick Overview for FAM105B 抗体 (AA 75-125) (ABIN7452665)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 75-125
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原理
- Rabbit anti-OTULIN Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 75 and 125
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亚型
- IgG
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anti-Family with Sequence Similarity 105, Member B (FAM105B) (AA 49-352) antibody
FAM105B 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 105, Member B (FAM105B) (AA 99-128) antibodyFAM105B 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB27178 unconjugated
anti-Family with Sequence Similarity 105, Member B (FAM105B) (AA 1-287) antibodyFAM105B 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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IP: 20-40 μL/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
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别名
- OTULIN
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背景
- Background: Otulin is a deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. [taken from the Universal Protein Resource (UniProt) Q96BN8].
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基因ID
- 90268
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UniProt
- Q96BN8
抗原
-
