CYLD 抗体 (C-Term) (HRP)
Quick Overview for CYLD 抗体 (C-Term) (HRP) (ABIN7174365)
抗原
See all CYLD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 269-435, C-Term
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Ubiquitin carboxyl-terminal hydrolase CYLD protein (269-435AA)
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亚型
- IgG
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anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 170-338) antibody
CYLD 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 654-953) antibodyCYLD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (C-Term) antibodyCYLD 适用: 人, 小鼠 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 204-358) antibodyCYLD 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5F7F4 unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (pSer418) antibodyCYLD 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 269-435), (C-Term) antibodyCYLD 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 32-45) antibodyCYLD 适用: 人, 小鼠, Hamster, 小鸡, Cow, 犬, 豚鼠, 马, 猴, 兔 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 305-582) antibodyCYLD 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 1667CT857-3-6-1 unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 854-953) antibodyCYLD 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 854-953) antibodyCYLD 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3A9 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
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别名
- CYLD
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背景
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Background: Deubiquitinase that specifically cleaves \'Lys-63\'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear (\'Met-1\'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26670046, PubMed:26997266).
Aliases: BRSS antibody, CDMT antibody, Cyld antibody, CYLD gene antibody, CYLD_HUMAN antibody, CYLD1 antibody, CYLDI antibody, cylindromatosis (turban tumor syndrome) antibody, cylindromatosis 1 antibody, Deubiquitinating enzyme CYLD antibody, EAC antibody, HSPC057 antibody, KIAA0849 antibody, MFT antibody, MFT1 antibody, Probable ubiquitin carboxyl terminal hydrolase CYLD antibody, SBS antibody, TEM antibody, turban tumor syndrome antibody, Ubiquitin carboxyl-terminal hydrolase CYLD antibody, ubiquitin specific peptidase like 2 antibody, ubiquitin thioesterase CYLD antibody, Ubiquitin thiolesterase CYLD antibody, Ubiquitin-specific processing protease CYLD antibody, Ubiquitin-specific-processing protease CYLD antibody, USPL2 antibody
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UniProt
- Q9NQC7
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途径
- Apoptosis, Activation of Innate immune Response
抗原
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