Ubiquilin 1 抗体 (AA 1-300)
Our Local Distributor
北京 101111
Quick Overview for Ubiquilin 1 抗体 (AA 1-300) (ABIN7174224)
抗原
See all Ubiquilin 1 (UBQLN1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-300
-
原理
- UBQLN1 Antibody
-
纯化方法
- Protein G purified
-
纯度
- >95 %
-
免疫原
- Recombinant Human Ubiquilin-1 protein (1-300AA)
-
亚型
- IgG
-
-
anti-Ubiquilin 1 (UBQLN1) (AA 290-339) antibody
UBQLN1 适用: 人, Cow, 犬, 豚鼠, 马, 兔, 绵羊, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 296-326) antibodyUBQLN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 1-589) antibodyUBQLN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C6-B7 unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 1-589) antibodyUBQLN1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C6-A3 unconjugated
anti-Ubiquilin 1 (UBQLN1) (Internal Region) antibodyUBQLN1 适用: 人 WB, ELISA, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal 3D5E2 unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 296-326) antibodyUBQLN1 适用: 人, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB4554 unconjugated
anti-Ubiquilin 1 (UBQLN1) antibodyUBQLN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 19-49), (N-Term) antibodyUBQLN1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4615 unconjugated
anti-Ubiquilin 1 (UBQLN1) (AA 40-70) antibodyUBQLN1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 1 (UBQLN1) antibodyUBQLN1 适用: 人, 小鼠 WB, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- Ubiquilin 1 (UBQLN1)
-
别名
- UBQLN1
-
背景
-
Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).
Aliases: DA41 antibody, DSK2 antibody, FLJ90054 antibody, hPLIC-1 antibody, hPLIC1 antibody, PLIC-1 antibody, PLIC1 antibody, Protein linking IAP with cytoskeleton 1 antibody, Ubiquilin-1 antibody, Ubiquilin1 antibody, UBQL1_HUMAN antibody, UBQLN1 antibody, UBQN antibody, XDRP1 antibody
-
UniProt
- Q9UMX0
抗原
-
