BLK 抗体 (AA 1-280)
Quick Overview for BLK 抗体 (AA 1-280) (ABIN7174010)
抗原
See all BLK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-280
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交叉反应
- 人, 小鼠
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA)
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亚型
- IgG
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anti-B Lymphoid Tyrosine Kinase (BLK) (AA 241-494) antibody
BLK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) (AA 1-90) antibodyBLK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7A12 unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) antibodyBLK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E5-3A8 unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) antibodyBLK 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) antibodyBLK 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 9D10B7 unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) (AA 1-30), (N-Term) antibodyBLK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03107 unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) antibodyBLK 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) antibodyBLK 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 9D10D1 unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) (N-Term) antibodyBLK 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-B Lymphoid Tyrosine Kinase (BLK) (AA 1-280) antibodyBLK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- BLK (B Lymphoid Tyrosine Kinase (BLK))
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别名
- BLK
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背景
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Background: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at \\\'Tyr-188\\\'and \\\'Tyr-199\\\', as well as CD79B at \\\'Tyr-196\\\' and \\\'Tyr-207\\\'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
Aliases: B lymphocyte kinase antibody, B lymphoid tyrosine kinase antibody, Blk antibody, BLK nonreceptor tyrosine kinase antibody, BLK_HUMAN antibody, EC 2.7.10.2 antibody, MGC 10442 antibody, MGC10442 antibody, MODY 11 antibody, MODY11 antibody, P55 BLK antibody, p55-BLK antibody, Tyrosine kinase B lymphocyte specific antibody, Tyrosine protein kinase antibody, Tyrosine-protein kinase BLK antibody
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UniProt
- P51451
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途径
- Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
抗原
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