TBCD 抗体 (AA 2-96)
Quick Overview for TBCD 抗体 (AA 2-96) (ABIN7173750)
抗原
See all TBCD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-96
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Tubulin-specific chaperone D protein (2-96AA)
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亚型
- IgG
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anti-Tubulin Folding Cofactor D (TBCD) (AA 1-623) antibody
TBCD 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tubulin Folding Cofactor D (TBCD) (AA 299-348) antibodyTBCD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Folding Cofactor D (TBCD) (N-Term) antibodyTBCD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Folding Cofactor D (TBCD) (N-Term) antibodyTBCD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TBCD (Tubulin Folding Cofactor D (TBCD))
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别名
- TBCD
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背景
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Background: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).
Aliases: Beta tubulin cofactor D antibody, Beta-tubulin cofactor D antibody, KIAA0988 antibody, SSD 1 antibody, SSD-1 antibody, SSD1 antibody, tbcd antibody, TBCD_HUMAN antibody, tfcD antibody, Tubulin folding cofactor D antibody, Tubulin specific chaperone D antibody, Tubulin-folding cofactor D antibody, Tubulin-specific chaperone D antibody
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UniProt
- Q9BTW9
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途径
- Cell-Cell Junction Organization
抗原
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