我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

VCP 抗体 (AA 704-806)

Name: VCP 抗体 (AA 704-806)
Brand: antibodies-online
SKU: ABIN7172893
Availability: OutOfStock

This anti-VCP antibody is a 兔多克隆 antibody detecting VCP in WB, IHC 和 ELISA. Suitable for 人.

Western Blot Positive WB detected in: Raw264. (VCP 抗体 (AA 704-806))

Immunohistochemistry of paraffin-embedded human testis tissue using ABIN7172893 at dilution of 1:100 (VCP 抗体 (AA 704-806))

IHC

2 images

产品编号 ABIN7172893

发货至: 中国

Datasheet as PDF

Quick Overview for VCP 抗体 (AA 704-806) (ABIN7172893)

抗原

See all VCP 抗体

VCP (Valosin Containing Protein (VCP))

适用

人

宿主

兔

克隆类型

多克隆

标记

This VCP antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Discover our top product VCP Primary Antibody

抗原表位
12

10

10

8

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 704-806

交叉反应

人

纯化方法

>95%, Protein G purified

免疫原

Recombinant Human Transitional endoplasmic reticulum ATPase protein (704-806AA)

亚型

IgG
anti-Valosin Containing Protein (VCP) (N-Term) antibody
VCP 适用: 人 WB, IF, IP, IHC (p), ICC, IHC (wm) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (C-Term) antibody
KO Validated VCP 适用: 人 WB, IF, IP, IHC (p), ICC, IHC (fro), IHC (wm) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 125-371) antibody
VCP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 1-588) antibody
VCP 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4A8 unconjugated

anti-Valosin Containing Protein (VCP) (AA 647-806) antibody
VCP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) antibody
VCP 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Monoclonal 5H12 unconjugated Recombinant Antibody

anti-Valosin Containing Protein (VCP) antibody
VCP 适用: 人, 小鼠 WB, FACS, ICC 宿主: 小鼠 Monoclonal Hs-14 unconjugated

anti-Valosin Containing Protein (VCP) (AA 749-766), (C-Term) antibody
VCP 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 732-760), (C-Term) antibody
VCP 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Valosin Containing Protein (VCP) (AA 732-760) antibody
VCP 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

限制

仅限研究用
状态

Liquid

缓冲液

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

VCP (Valosin Containing Protein (VCP))

别名

VCP

背景

Background: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via \\\'Lys-63\\\'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).
Aliases: 15S Mg(2+) ATPase p97 subunit antibody, 15S Mg(2+)-ATPase p97 subunit antibody, ALS14 antibody, ATPase p97 antibody, CDC48 antibody, IBMPFD antibody, MGC131997 antibody, MGC148092 antibody, MGC8560 antibody, p97 antibody, TER ATPase antibody, TERA antibody, TERA_HUMAN antibody, Transitional endoplasmic reticulum ATPase antibody, Valosin containing protein antibody, Valosin-containing protein antibody, VCP antibody, Yeast Cdc48p homolog antibody

UniProt

P55072

途径

ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway