TFEB 抗体 (AA 1-476)
Quick Overview for TFEB 抗体 (AA 1-476) (ABIN7172536)
抗原
See all TFEB 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-476
-
交叉反应
- 人, 大鼠
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human Transcription factor EB protein (1-476AA)
-
亚型
- IgG
-
-
-
-
应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- TFEB (Transcription Factor EB (TFEB))
-
别名
- TFEB
-
背景
-
Background: Transcription factor that specifically recognizes and binds E-box sequences (5\\\'-CANNTG-3\\\'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5\\\'-GTCACGTGAC-3\\\') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Aliases: Alpha TFEB antibody, AlphaTFEB antibody, bHLHe35 antibody, Class E basic helix-loop-helix protein 35 antibody, T cell transcription factor EB antibody, TCFEB antibody, TFEB antibody, TFEB_HUMAN antibody, Transcription factor EB antibody
-
UniProt
- P19484
抗原
-