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TFEB 抗体 (AA 1-220)

This anti-TFEB antibody is a 兔 多克隆 antibody detecting TFEB in WB, ELISA 和 IHC. Suitable for 人.
产品编号 ABIN7172534
发货至: 中国

Quick Overview for TFEB 抗体 (AA 1-220) (ABIN7172534)

抗原

See all TFEB 抗体
TFEB (Transcription Factor EB (TFEB))

适用

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宿主

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克隆类型

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多克隆

标记

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This TFEB antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    AA 1-220

    交叉反应

    人, 小鼠

    纯化方法

    Antigen Affinity Purified

    免疫原

    Recombinant Human Transcription factor EB protein (1-220AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    TFEB (Transcription Factor EB (TFEB))

    别名

    TFEB

    背景

    Background: Transcription factor that specifically recognizes and binds E-box sequences (5\\\'-CANNTG-3\\\'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5\\\'-GTCACGTGAC-3\\\') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

    Aliases: Alpha TFEB antibody, AlphaTFEB antibody, bHLHe35 antibody, Class E basic helix-loop-helix protein 35 antibody, T cell transcription factor EB antibody, TCFEB antibody, TFEB antibody, TFEB_HUMAN antibody, Transcription factor EB antibody

    UniProt

    P19484
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