TICAM2 抗体 (AA 1-235)
Quick Overview for TICAM2 抗体 (AA 1-235) (ABIN7172205)
抗原
See all TICAM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-235
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human TIR domain-containing adapter molecule 2 protein (1-235AA)
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亚型
- IgG
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anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (C-Term) antibody
TICAM2 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 150-200) antibodyTICAM2 适用: 人, 小鼠, 大鼠, 猴, Cow, Opossum WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (C-Term) antibodyTICAM2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 34-241) antibodyTICAM2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))
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别名
- TICAM2
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背景
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Background: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB, however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Aliases: Putative NF-kappa-B-activating protein 502 antibody, TCAM2_HUMAN antibody, TICAM-2 antibody, TICAM2 antibody, TIR containing adapter molecule 2 antibody, TIR domain containing adaptor protein antibody, TIR domain-containing adapter molecule 2 antibody, TIRAP 3 antibody, TIRAP3 antibody, TIRAP3a short form antibody, TIRP antibody, Toll-like receptor adaptor protein 3 antibody, Toll/interleukin-1 receptor domain-containing protein antibody, TRAM antibody, TRIF-related adapter molecule antibody
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UniProt
- Q86XR7
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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