TREX1 抗体 (AA 1-270)
Quick Overview for TREX1 抗体 (AA 1-270) (ABIN7172071)
抗原
See all TREX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-270
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Three-prime repair exonuclease 1 protein (1-270AA)
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亚型
- IgG
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anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-369) antibody
TREX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-270) antibodyTREX1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-304) antibodyTREX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-100) antibodyTREX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F10 unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 6-369) antibodyTREX1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-304) antibodyTREX1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-100) antibodyTREX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-369) antibodyTREX1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) antibodyTREX1 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (Center) antibodyTREX1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
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别名
- TREX1
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背景
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Background: Major cellular 3\\\'-to-5\\\' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3\\\' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3\\\' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Aliases: TREX1 antibody, Three-prime repair exonuclease 1 antibody, EC 3.1.11.2 antibody, 3'-5' exonuclease TREX1 antibody, Deoxyribonuclease III antibody, DNase III antibody
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UniProt
- Q9NSU2
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途径
- Apoptosis
抗原
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