SUFUH 抗体 (AA 325-484)
Quick Overview for SUFUH 抗体 (AA 325-484) (ABIN7171013)
抗原
See all SUFUH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 325-484
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交叉反应
- 人, 小鼠
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Suppressor of fused homolog protein (325-484AA)
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亚型
- IgG
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anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibody
SUFUH 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 433-484) antibodySUFUH 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 308-341), (C-Term) antibodySUFUH 适用: 人 WB 宿主: 兔 Polyclonal RB53250 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH 适用: 人, 小鼠, Green Monkey WB, IHC (p) 宿主: 小鼠 Monoclonal 1783CT536-263-29 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (C-Term) antibodySUFUH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Pig, Bat, 猴, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 1-484) antibodySUFUH 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 181-280) antibodySUFUH 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 1B2 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (Middle Region) antibodySUFUH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 215-264) antibodySUFUH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Pig, Bat, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SUFUH (Suppressor of Fused Homolog (SUFUH))
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别名
- SUFU
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背景
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Background: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation.
Aliases: OTTHUMP00000020374 antibody, OTTHUMP00000020377 antibody, OTTHUMP00000020379 antibody, PRO1280 antibody, SU FU antibody, SU(F)U antibody, Su(fu) antibody, SUFU antibody, SUFU negative regulator of hedgehog signaling antibody, SUFU_HUMAN antibody, SUFUH antibody, SUFUXL antibody, Suppressor of Fused antibody, Suppressor of fused homolog (Drosophila) antibody, Suppressor of fused homolog antibody
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UniProt
- Q9UMX1
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途径
- Hedgehog Signaling, Tube Formation, Maintenance of Protein Location
抗原
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