CXCL12 抗体 (AA 22-89) (FITC)
Our Local Distributor
北京 101111
Quick Overview for CXCL12 抗体 (AA 22-89) (FITC) (ABIN7170827)
抗原
See all CXCL12 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 22-89
-
原理
- CXCL12 Antibody,FITC conjugated
-
纯化方法
- Antigen Affinity purified & Affinity purified
-
纯度
- >95 %
-
免疫原
- Recombinant Human Stromal cell-derived factor 1 protein (22-89AA)
-
亚型
- IgG
-
-
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibody
CXCL12 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibodyCXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibodyCXCL12 适用: 人 WB, IHC, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibodyCXCL12 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibodyCXCL12 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人, 小鼠, 犬, 小鸡, 非洲爪蟾, Bat, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibodyCXCL12 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 24-70) antibodyCXCL12 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
-
别名
- CXCL12
-
背景
-
Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody, AI174028 antibody, C-X-C motif chemokine 12 antibody, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody, Chemokine (C-X-C motif) ligand 12 antibody, Chemokine CXC motif ligand 12 antibody, cxcl12 antibody, hIRH antibody, hSDF-1 antibody, Intercrine reduced in hepatomas antibody, IRH antibody, OTTHUMP00000019491 antibody, PBSF antibody, Pre-B cell growth-stimulating factor antibody, SCYB12 antibody, SDF 1 antibody, SDF-1 antibody, SDF-1-alpha(3-67) antibody, SDF-1a antibody, SDF-1b antibody, SDF1_HUMAN antibody, SDF1A antibody, SDF1B antibody, Stromal cell-derived factor 1 antibody, Stromal cell-derived factor 1 delta antibody, Stromal cell-derived factor 1 gamma antibody, Stromal cell-derived factor 1a antibody, Stromal cell-derived factor-1 alpha antibody, Thymic lymphoma cell-stimulating factor antibody, Tlsf antibody, TLSF-a antibody, TLSF-b antibody, Tlsfa antibody, Tlsfb antibody, TPAR1 antibody
-
UniProt
- P48061
-
途径
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
抗原
-
