CXCL12 抗体 (AA 24-70)
(3 references)-
- 抗原 See all CXCL12 抗体
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
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抗原表位
- AA 24-70
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CXCL12 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Dog,Pig,Chicken,Guinea Pig
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SDF-1/CXCL12
- 亚型
- IgG
- Top Product
- Discover our top product CXCL12 Primary Antibody
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anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibodyCXCL12 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibodyCXCL12 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 31-80) antibodyCXCL12 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibodyCXCL12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人, 小鼠, 犬, 小鸡, 非洲爪蟾, Bat, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibodyCXCL12 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibodyCXCL12 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, (2016) (PubMed).
: "Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis." in: Autophagy, (2015) (PubMed).
: "Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 9, Issue 2, pp. 255-64, (2014) (PubMed).
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: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, (2016) (PubMed).
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- 抗原
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
- 别名
- SDF1 (CXCL12 产品)
- 别名
- IRH antibody, PBSF antibody, SCYB12 antibody, SDF1 antibody, TLSF antibody, TPAR1 antibody, CINC-1 antibody, Gro1 antibody, Pbsf antibody, Scyb12 antibody, Sdf1 antibody, Tlsf antibody, Tpar1 antibody, Fsp antibody, KC antibody, Mgsa antibody, N51 antibody, Scyb1 antibody, gro antibody, sdf-1 antibody, sdf1 antibody, xSDF-1 antibody, SDF-1 antibody, cxcl12 antibody, sdf-1a antibody, sdf1a antibody, wu:fa55e10 antibody, wu:fc16h12 antibody, wu:fj84c02 antibody, C-X-C motif chemokine ligand 12 antibody, C-X-C motif chemokine ligand 1 antibody, chemokine (C-X-C motif) ligand 12 antibody, chemokine (C-X-C motif) ligand 1 antibody, C-X-C motif chemokine ligand 12 L homeolog antibody, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antibody, CXCL12 antibody, cxcl12 antibody, Cxcl1 antibody, Cxcl12 antibody, cxcl12.L antibody, cxcl12a antibody
- 背景
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Synonyms: IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12, Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, hIRH, Pre-B cell growth-stimulating factor, CXCL12, SDF1A, SDF1B
Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
- 基因ID
- 6387
- UniProt
- P48061
- 途径
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
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