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- 抗原 See all CXCL12 抗体
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
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抗原表位
- AA 22-89
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CXCL12 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Antigen Affinity purified & Affinity purified
- 免疫原
- Recombinant Human Stromal cell-derived factor 1 protein (22-89AA)
- 亚型
- IgG
- Top Product
- Discover our top product CXCL12 Primary Antibody
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anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibodyCXCL12 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibodyCXCL12 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 31-80) antibodyCXCL12 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibodyCXCL12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人, 小鼠, 犬, 小鸡, 非洲爪蟾, Bat, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibodyCXCL12 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 24-70) antibodyCXCL12 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibodyCXCL12 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibodyCXCL12 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
- 别名
- CXCL12 (CXCL12 产品)
- 别名
- IRH antibody, PBSF antibody, SCYB12 antibody, SDF1 antibody, TLSF antibody, TPAR1 antibody, CINC-1 antibody, Gro1 antibody, Pbsf antibody, Scyb12 antibody, Sdf1 antibody, Tlsf antibody, Tpar1 antibody, Fsp antibody, KC antibody, Mgsa antibody, N51 antibody, Scyb1 antibody, gro antibody, sdf-1 antibody, sdf1 antibody, xSDF-1 antibody, SDF-1 antibody, cxcl12 antibody, sdf-1a antibody, sdf1a antibody, wu:fa55e10 antibody, wu:fc16h12 antibody, wu:fj84c02 antibody, C-X-C motif chemokine ligand 12 antibody, C-X-C motif chemokine ligand 1 antibody, chemokine (C-X-C motif) ligand 12 antibody, chemokine (C-X-C motif) ligand 1 antibody, C-X-C motif chemokine ligand 12 L homeolog antibody, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antibody, CXCL12 antibody, cxcl12 antibody, Cxcl1 antibody, Cxcl12 antibody, cxcl12.L antibody, cxcl12a antibody
- 背景
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Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody, AI174028 antibody, C-X-C motif chemokine 12 antibody, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody, Chemokine (C-X-C motif) ligand 12 antibody, Chemokine CXC motif ligand 12 antibody, cxcl12 antibody, hIRH antibody, hSDF-1 antibody, Intercrine reduced in hepatomas antibody, IRH antibody, OTTHUMP00000019491 antibody, PBSF antibody, Pre-B cell growth-stimulating factor antibody, SCYB12 antibody, SDF 1 antibody, SDF-1 antibody, SDF-1-alpha(3-67) antibody, SDF-1a antibody, SDF-1b antibody, SDF1_HUMAN antibody, SDF1A antibody, SDF1B antibody, Stromal cell-derived factor 1 antibody, Stromal cell-derived factor 1 delta antibody, Stromal cell-derived factor 1 gamma antibody, Stromal cell-derived factor 1a antibody, Stromal cell-derived factor-1 alpha antibody, Thymic lymphoma cell-stimulating factor antibody, Tlsf antibody, TLSF-a antibody, TLSF-b antibody, Tlsfa antibody, Tlsfb antibody, TPAR1 antibody
- UniProt
- P48061
- 途径
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
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