STAMBP 抗体 (AA 1-424) (FITC)
Quick Overview for STAMBP 抗体 (AA 1-424) (FITC) (ABIN7170688)
抗原
See all STAMBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-424
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human STAM-binding protein (1-424AA)
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亚型
- IgG
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- STAMBP (STAM Binding Protein (STAMBP))
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别名
- STAMBP
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背景
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Background: Zinc metalloprotease that specifically cleaves \'Lys-63\'-linked polyubiquitin chains. Does not cleave \'Lys-48\'-linked polyubiquitin chains.Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization .Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Aliases: AMSH antibody, Associated molecule with the SH3 domain of STAM antibody, Endosome associated ubiquitin isopeptidase antibody, Endosome-associated ubiquitin isopeptidase antibody, MGC126516 antibody, MGC126518 antibody, MICCAP antibody, STABP_HUMAN antibody, STAM binding protein antibody, STAM-binding protein antibody, Stambp antibody
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UniProt
- O95630
抗原
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