Spindlin 1 抗体 (AA 1-262)
Quick Overview for Spindlin 1 抗体 (AA 1-262) (ABIN7170599)
抗原
See all Spindlin 1 (SPIN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-262
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Spindlin-1 protein (1-262AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Spindlin 1 (SPIN1)
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别名
- SPIN1
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背景
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Background: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at \\\'Lys-4\\\' and asymmetrically dimethylated at \\\'Arg-8\\\' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Aliases: OCR antibody, Ovarian cancer-related protein antibody, SPIN antibody, Spin1 antibody, SPIN1_HUMAN antibody, Spindlin-1 antibody
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UniProt
- Q9Y657
抗原
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