WNK4 抗体 (AA 828-1106) (Biotin)
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北京 101111
Quick Overview for WNK4 抗体 (AA 828-1106) (Biotin) (ABIN7169235)
抗原
See all WNK4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 828-1106
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原理
- WNK4 Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)
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亚型
- IgG
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anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 828-1106) antibody
WNK4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 1144-1243) antibodyWNK4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) (AA 351-450) antibodyWNK4 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) antibodyWNK4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))
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别名
- WNK4
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背景
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Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Aliases: PHA 2B antibody, PHA2B antibody, PRKWNK 4 antibody, PRKWNK4 antibody, Protein kinase lysine deficient 4 antibody, Protein kinase lysine-deficient 4 antibody, Protein kinase with no lysine 4 antibody, Serine/threonine protein kinase WNK4 antibody, Serine/threonine-protein kinase WNK4 antibody, WNK lysine deficient protein kinase 4 antibody, Wnk4 antibody, WNK4_HUMAN antibody
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UniProt
- Q96J92
抗原
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