BRSK1 抗体 (AA 426-591)
Quick Overview for BRSK1 抗体 (AA 426-591) (ABIN7169019)
抗原
See all BRSK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 426-591
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交叉反应
- 人, 小鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Serine/threonine-protein kinase BRSK1 protein (426-591AA)
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亚型
- IgG
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anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 310-510) antibody
BRSK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 355-384) antibodyBRSK1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40234 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (Internal Region) antibodyBRSK1 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 654-684), (C-Term) antibodyBRSK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB5415 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (C-Term) antibodyBRSK1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
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别名
- BRSK1
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背景
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Background: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at \\\'Thr-529\\\' and \\\'Ser-579\\\'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at \\\'Ser-642\\\' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at \\\'Ser-131\\\', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
Aliases: BR serine/threonine kinase 1 antibody, BR serine/threonine protein kinase 1 antibody, BR serine/threonine-protein kinase 1 antibody, Brain selective kinase 1 antibody, Brain-specific serine/threonine-protein kinase 1 antibody, BRSK 1 antibody, Brsk1 antibody, BRSK1_HUMAN antibody, FLJ43009 antibody, hSAD1 antibody, KIAA1811 antibody, Protein kinase SAD1A antibody, SAD 1 antibody, SAD1 antibody, SAD1 homolog antibody, SAD1 kinase antibody, SAD1A antibody, SADB antibody, SadB kinase short isoform antibody, Serine/threonine kinase SAD B antibody, Serine/threonine-protein kinase SAD-B antibody, Synapses of Amphids Defective homolog antibody
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UniProt
- Q8TDC3
抗原
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