SAV1 抗体 (AA 1-210)
Quick Overview for SAV1 抗体 (AA 1-210) (ABIN7166095)
抗原
See all SAV1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-210
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Protein salvador homolog 1 protein (1-210AA)
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亚型
- IgG
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anti-Salvador Homolog 1 (SAV1) (AA 300-383) antibody
SAV1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-210) antibodySAV1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-383) antibodySAV1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 300-383) antibodySAV1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 65-92) antibodySAV1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 266-315) antibodySAV1 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-383) antibodySAV1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:500, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SAV1 (Salvador Homolog 1 (SAV1))
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别名
- SAV1
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背景
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Background: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Aliases: 1700040G09Rik antibody, 45 kDa WW domain protein antibody, hWW 45 antibody, hWW45 antibody, Protein salvador homolog 1 antibody, salvador family WW domain containing protein 1 antibody, salvador homolog 1 (Drosophila) antibody, Salvador homolog 1 antibody, Salvador, Drosophila, homolog of antibody, SAV 1 antibody, SAV antibody, SAV1 antibody, SAV1_HUMAN antibody, WW 45 antibody, WW domain containing antibody, WW domain-containing adaptor 45 antibody, WW domain-containing protein, 45-KD antibody, WW45 antibody, WW45 protein antibody, WWP 4 antibody, WWP4 antibody
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UniProt
- Q9H4B6
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途径
- Stem Cell Maintenance
抗原
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