LIN28B 抗体 (AA 166-250)
Quick Overview for LIN28B 抗体 (AA 166-250) (ABIN7165750)
抗原
See all LIN28B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 166-250
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Protein lin-28 homolog B protein (166-250AA)
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亚型
- IgG
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anti-Lin-28 Homolog B (LIN28B) (AA 1-30) antibody
LIN28B 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 95-128) antibodyLIN28B 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) antibodyLIN28B 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 218-250) antibodyLIN28B 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 95-128) antibodyLIN28B 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 200-250) antibodyLIN28B 适用: 人, 猴 IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (N-Term) antibodyLIN28B 适用: 人 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (Center) antibodyLIN28B 适用: 人 WB, FACS, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Lin-28 Homolog B (LIN28B) (AA 218-250), (C-Term) antibodyLIN28B 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LIN28B (Lin-28 Homolog B (LIN28B))
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别名
- LIN28B
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背景
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Background: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5\'-GGAG-3\' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Aliases: CSDD 2 antibody, CSDD2 antibody, FLJ16517 antibody, Lin 28 homolog B (C. elegans) antibody, Lin 28.2 antibody, Lin-28B antibody, LIN28B antibody, LN28B_HUMAN antibody, Protein lin-28 homolog B antibody
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UniProt
- Q6ZN17
抗原
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