PKD2 抗体 (AA 680-968)
Quick Overview for PKD2 抗体 (AA 680-968) (ABIN7163836)
抗原
See all PKD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 680-968
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Polycystin-2 protein (680-968AA)
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亚型
- IgG
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anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 261-360) antibody
PKD2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 4C8 unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 621-832) antibodyPKD2 适用: 人 ELISA, WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 327-539) antibodyPKD2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (pSer876) antibodyPKD2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 261-360) antibodyPKD2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 240-410) antibodyPKD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 651-750) antibodyPKD2 适用: 人, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (Internal Region) antibodyVerified PKD2 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (Tyr654) antibodyPKD2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (C-Term) antibodyPKD2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))
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别名
- PKD2
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背景
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Background: Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow, forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).
Aliases: APKD2 antibody, Autosomal dominant polycystic kidney disease type II antibody, Autosomal dominant polycystic kidney disease type II protein antibody, MGC138466 antibody, MGC138468 antibody, PC 2 antibody, PC2 antibody, PKD 2 antibody, PKD2 antibody, PKD2_HUMAN antibody, PKD4 antibody, Polycystic kidney disease 2 (autosomal dominant) antibody, Polycystic kidney disease 2 antibody, Polycystic kidney disease 2 protein antibody, Polycystin 2 antibody, Polycystin 2 transient receptor potential cation channel antibody, Polycystin-2 antibody, Polycystin2 antibody, Polycystwin antibody, R48321 antibody, Transient receptor potential cation channel subfamily P member 2 antibody, TRPP2 antibody
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UniProt
- Q13563
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途径
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
抗原
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