PIK3R1 抗体 (Regulatory Subunit A)
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- 抗原 See all PIK3R1 (PI3K p85a) 抗体
- PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
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抗原表位
- AA 160-376, Regulatory Subunit A
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIK3R1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit alpha protein (160-376AA)
- 亚型
- IgG
- Top Product
- Discover our top product PI3K p85a Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
- 别名
- PIK3R1 (PI3K p85a 产品)
- 背景
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Background: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Aliases: GRB1 antibody, p85 alpha antibody, p85 antibody, P85A_HUMAN antibody, Phosphatidylinositol 3 kinase associated p 85 alpha antibody, Phosphatidylinositol 3 kinase regulatory 1 antibody, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody, Phosphatidylinositol 3-kinase regulatory subunit alpha antibody, Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody, PI3 kinase p85 antibody, PI3 kinase p85 subunit alpha antibody, PI3-kinase regulatory subunit alpha antibody, PI3-kinase subunit p85-alpha antibody, PI3K antibody, PI3K p85 antibody, PI3K regulatory subunit alpha antibody, Pik3r1 antibody, PtdIns 3 kinase p85 alpha antibody, PtdIns-3-kinase regulatory subunit alpha antibody, PtdIns-3-kinase regulatory subunit p85-alpha antibody
- UniProt
- P27986
- 途径
- TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect
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