PPID 抗体 (AA 161-370)
Quick Overview for PPID 抗体 (AA 161-370) (ABIN7162803)
抗原
See all PPID 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-370
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交叉反应
- 人, 小鼠
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Peptidyl-prolyl cis-trans isomerase D protein (161-370AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PPID (Peptidylprolyl Isomerase D (PPID))
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别名
- PPID
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背景
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Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer, the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.
Aliases: 40 kDa peptidyl-prolyl cis-trans isomerase antibody, 40 kDa peptidyl-prolyl cis-trans isomerase D antibody, Cyclophilin related protein antibody, Cyclophilin-40 antibody, Cyclophilin-related protein antibody, CYP-40 antibody, CYP40 antibody, CYPD antibody, Estrogen receptor-binding cyclophilin antibody, Peptidyl-prolyl cis-trans isomerase D antibody, Peptidylprolyl isomerase D antibody, PPIase D antibody, Ppid antibody, PPID_HUMAN antibody, Rotamase antibody, Rotamase D antibody
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UniProt
- Q08752
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途径
- Nuclear Hormone Receptor Binding
抗原
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