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- 抗原 See all NLRP6 抗体
- NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))
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抗原表位
- AA 154-306
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NLRP6 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human NACHT, LRR and PYD domains-containing protein 6 protein (154-306AA)
- 亚型
- IgG
- Top Product
- Discover our top product NLRP6 Primary Antibody
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anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 351-450) antibody
NLRP6 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (fro), ICC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) antibodyNLRP6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 100-200) antibodyNLRP6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) antibodyNLRP6 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal Clint-1 unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 168-197), (N-Term) antibodyNLRP6 适用: 人 WB 宿主: 兔 Polyclonal RB33587 unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 168-197) antibodyNLRP6 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 343-372) antibodyNLRP6 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (N-Term) antibodyNLRP6 适用: 人 ELISA, WB, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))
- 别名
- NLRP6 (NLRP6 产品)
- 别名
- NLRP6 antibody, NALP6 antibody, AVR antibody, CLR11.4 antibody, NAVR antibody, NAVR/AVR antibody, PAN3 antibody, PYPAF5 antibody, AI504961 antibody, Avr antibody, Nalp6 antibody, Navr antibody, Navr/Avr antibody, Pypaf5 antibody, NLR family pyrin domain containing 6 antibody, NLR family, pyrin domain containing 6 antibody, NLRP6 antibody, Nlrp6 antibody
- 背景
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Background: As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).
Aliases: Angiotensin II/vasopressin receptor antibody, AVR antibody, CLR11.4 antibody, NACHT, leucine rich repeat and PYD containing 6 antibody, NACHT, LRR and PYD containing protein 6 antibody, NACHT, LRR and PYD domains-containing protein 6 antibody, NAVR antibody, NAVR/AVR antibody, NLR family, pyrin domain containing 6 antibody, Nlrp6 antibody, NLRP6_HUMAN antibody, Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody, PAN3 antibody, PYPAF5 antibody, PYRIN containing APAF1 like protein 5 antibody, PYRIN-containing APAF1-like protein 5 antibody
- UniProt
- P59044
- 途径
- Inflammasome
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