NLRP6 抗体
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北京 101111
Quick Overview for NLRP6 抗体 (ABIN1169061)
抗原
See all NLRP6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-NLRP6/NALP6 (human), mAb (Clint-1)
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特异性
- Recognizes human NLRP6.
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产品特性
- Monoclonal Antibody. Recognizes human NLRP6. Isotype: Mouse IgG1kappa. Clone: Clint-1. Applications: IHC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human NLRP6 (NACHT domain).
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亚型
- IgG1 kappa
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anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 351-450) antibody
NLRP6 适用: 人 IF (cc), IF (p), IHC (p), IHC (fro), IP 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) antibodyNLRP6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 168-197), (N-Term) antibodyNLRP6 适用: 人 WB 宿主: 兔 Polyclonal RB33587 unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) antibodyNLRP6 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 154-306) antibodyNLRP6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 343-372) antibodyNLRP6 适用: 小鼠 ELISA, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (AA 168-197) antibodyNLRP6 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (N-Term) antibodyNLRP6 适用: 人 ELISA, WB, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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- NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))
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别名
- NLRP6/NALP6
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背景
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Alternate Names/Synonyms: NACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor, PYRIN-containing APAF1-like Protein 5, NALP6
Product Description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
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UniProt
- P59044
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途径
- Inflammasome
抗原
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