NLRP1 抗体 (AA 1-146)
Quick Overview for NLRP1 抗体 (AA 1-146) (ABIN7160817)
抗原
See all NLRP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-146
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human NACHT, LRR and PYD domains-containing protein 1 protein (1-146AA)
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亚型
- IgG
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anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 1000-1100) antibody
NLRP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 589-655) antibodyNLRP1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 323-372) antibodyNLRP1 适用: 人, 小鼠, Cow, 犬, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (C-Term) antibodyNLRP1 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) antibodyNLRP1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 1-1429) antibodyNLRP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 2-25), (N-Term) antibodyNLRP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (N-Term) antibodyNLRP1 适用: 人, 小鼠, Cow, 犬, 马, 大鼠, 豚鼠, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (C-Term) antibodyNLRP1 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
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别名
- NLRP1
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背景
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Background: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).
Aliases: CARD 7 antibody, CARD7 antibody, Caspase recruitment domain protein 7 antibody, Caspase recruitment domain-containing protein 7 antibody, CLR17.1 antibody, Death effector filament forming Ced 4 like apoptosis protein antibody, Death effector filament-forming ced-4-like apoptosis protein antibody, DEFCAP antibody, DEFCAP L/S antibody, DKFZp586O1822 antibody, KIAA0926 antibody, LRR and PYD domains-containing protein 1 antibody, NAC alpha/beta/gamma/delta antibody, NAC antibody, NACHT antibody, NACHT leucine rich repeat and PYD containing 1 antibody, NACHT leucine rich repeat and PYD pyrin domain containing 1 antibody, NACHT leucine rich repeat and pyrin domain containing 1 antibody, NACHT LRR and PYD containing protein 1 antibody, NALP 1 antibody, NALP1 antibody, NALP1_HUMAN antibody, NLR family pyrin domain containing 1 antibody, NLRP 1 antibody, NLRP1 antibody, NLRP1 protein antibody, Nucleotide binding domain and caspase recruitment domain antibody, Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 1 antibody, Nucleotide-binding domain and caspase recruitment domain antibody, PP 1044 antibody, PP1044 antibody
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UniProt
- Q9C000
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途径
- Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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