SMAD4 抗体 (AA 27-195) (HRP)
Quick Overview for SMAD4 抗体 (AA 27-195) (HRP) (ABIN7160241)
抗原
See all SMAD4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 27-195
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Mothers against decapentaplegic homolog 4 protein (27-195AA)
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亚型
- IgG
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anti-SMAD Family Member 4 (SMAD4) (N-Term) antibody
SMAD4 适用: 人 WB, IP, CUT&RUN 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 1-552) antibodySMAD4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodyKO Validated SMAD4 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodySMAD4 适用: 人, 小鼠 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4G1C6 unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 400-428) antibodySMAD4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 27-195) antibodySMAD4 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 255-284) antibodySMAD4 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB14714 unconjugated
anti-SMAD Family Member 4 (SMAD4) (pThr277) antibodySMAD4 适用: 人 ELISA, IHC, IF, DB 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodySMAD4 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 3A1 unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 9-231) antibodySMAD4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SMAD4 (SMAD Family Member 4 (SMAD4))
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别名
- SMAD4
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背景
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Background: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5\'-GTCT/AGAC-3\') within BMP response element (BMPRE) of cardiac activating regions. Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Aliases: (Small) Mothers Against Decapentaplegic antibody, Deleted in Pancreatic Carcinoma 4 antibody, Deleted in Pancreatic Carcinoma antibody, Deleted in pancreatic carcinoma locus 4 antibody, Deletion target in pancreatic carcinoma 4 antibody, DPC 4 antibody, DPC4 antibody, hSMAD4 antibody, JIP antibody, MAD homolog 4 antibody, MAD mothers against decapentaplegic Drosophila homolog 4 antibody, MAD mothers against decapentaplegic homolog 4 antibody, MADH 4 antibody, MADH4 antibody, Med antibody, Medea antibody, Mothers against decapentaplegic homolog 4 antibody, Mothers against decapentaplegic, Drosophila, homolog of, 4 antibody, Mothers against DPP homolog 4 antibody, MYHRS antibody, OTTHUMP00000163548 antibody, SMA- and MAD-related protein 4 antibody, SMAD 4 antibody, SMAD family member 4 antibody, SMAD mothers against DPP homolog 4 antibody, SMAD4 antibody, SMAD4_HUMAN antibody
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UniProt
- Q13485
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途径
- Cell Division Cycle, Chromatin Binding, Autophagy
抗原
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