MAP3K8 抗体 (AA 1-300) (Biotin)
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北京 101111
Quick Overview for MAP3K8 抗体 (AA 1-300) (Biotin) (ABIN7160058)
抗原
See all MAP3K8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-300
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原理
- MAP3K8 Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Mitogen-activated protein kinase kinase kinase 8 protein (1-300AA)
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 121-220) antibody
MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 1-300) antibodyMAP3K8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pThr290) antibodyMAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) antibodyMAP3K8 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 256-305) antibodyMAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (Ser400) antibodyMAP3K8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (AA 368-397), (C-Term) antibodyMAP3K8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB03467 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pSer290) antibodyMAP3K8 适用: 人, 大鼠, 小鼠, Cow, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pThr290) antibodyMAP3K8 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pSer400) antibodyMAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
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别名
- MAP3K8
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背景
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Background: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
Aliases: AURA2 antibody, c COT antibody, Cancer Osaka thyroid oncogene antibody, CCOT antibody, COT antibody, COT proto oncogene serine/threonine protein kinase antibody, EST antibody, ESTF antibody, Ewing sarcoma transformant antibody, FLJ10486 antibody, M3K8_HUMAN antibody, MAP3K 8 antibody, MAP3K8 antibody, MEKK8 antibody, Mitogen activated protein kinase kinase kinase 8 antibody, Mitogen-activated protein kinase kinase kinase 8 antibody, Proto oncogene cCot antibody, Proto-oncogene c-Cot antibody, Serine/threonine protein kinase cot antibody, Serine/threonine-protein kinase cot antibody, TPL 2 antibody, TPL-2 antibody, TPL2 antibody, Tumor progression locus 2 antibody
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UniProt
- P41279
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途径
- PI3K-Akt Signaling, TCR Signaling
抗原
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