MFN2 抗体 (AA 61-158)
Quick Overview for MFN2 抗体 (AA 61-158) (ABIN7159968)
抗原
See all MFN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 61-158
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交叉反应
- 人, 大鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Mitofusin-2 protein (61-158AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:200-1:3000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- MFN2 (Mitofusin 2 (MFN2))
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别名
- MFN2
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背景
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Background: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Aliases: CMT2A antibody, CMT2A2 antibody, CPRP 1 antibody, CPRP1 antibody, EC 3.6.5.- antibody, Fzo antibody, HSG antibody, hyperplasia suppressor gene antibody, Hypertension related protein 1 antibody, KIAA0214 antibody, MARF antibody, MFN 2 antibody, Mfn2 antibody, MFN2_HUMAN antibody, Mitochondrial assembly regulatory factor antibody, Mitofusin-2 antibody, Mitofusin2 antibody, Transmembrane GTPase MFN2 antibody
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UniProt
- O95140
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途径
- Skeletal Muscle Fiber Development
抗原
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