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PKC theta 抗体 (pThr538)

Name: PKC theta 抗体 (pThr538)
SKU: ABIN711746
Availability: OutOfStock

Cited in 1 publication. This 兔多克隆 anti-PKC theta antibody specifically detects PKC theta in WB, ELISA, IHC (p), IF (cc), IF (p) 和 IHC (fro). The antibody is reactive with 人和小鼠 samples.

Formalin-fixed and paraffin embedded human endometrial carcinoma labeled with Anti-phospho-PRKCQ(Thr538) Polyclonal Antibody, Unconjugated (ABIN711746) at 1:200 followed by conjugation to the secondary antibody (PKC theta 抗体 (pThr538))

IHC

1 image

(1 reference)

产品编号 ABIN711746

发货至: 中国

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Quick Overview for PKC theta 抗体 (pThr538) (ABIN711746)

抗原

See all PKC theta (PRKCQ) 抗体

PKC theta (PRKCQ) (Protein Kinase C, theta (PRKCQ))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This PKC theta antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product PRKCQ Primary Antibody

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pThr538

交叉反应

人, 小鼠

预测反应

Rat,Dog

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human PRKCQ around the phosphorylation site of Thr538

亚型

IgG
anti-Protein Kinase C, theta (PRKCQ) (pSer676) antibody
PRKCQ 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) (AA 380-634) antibody
PRKCQ 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) (AA 15-294) antibody
PRKCQ 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) antibody
PRKCQ 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4105 unconjugated Recombinant Antibody

anti-Protein Kinase C, theta (PRKCQ) (pSer695) antibody
PRKCQ 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) (C-Term) antibody
PRKCQ 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) (C-Term), (pSer676) antibody
PRKCQ 适用: 人, 大鼠, 小鼠, Cow, 犬, Pig, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) (AA 351-450) antibody
PRKCQ 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) (AA 1-230) antibody
PRKCQ 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, theta (PRKCQ) antibody
PRKCQ 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 1B2 unconjugated Recombinant Antibody

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
van Rees, Lago, Cox, Tomasik, Rustogi, Weigelt, Ozcan, Cooper, Drexhage, Leweke, Bahn: "Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients." in: Brain, behavior, and immunity, Vol. 67, pp. 364-373, (2018) (PubMed).
抗原

PKC theta (PRKCQ) (Protein Kinase C, theta (PRKCQ))

别名

PRKCQ

背景

Synonyms: PRKCT, nPKC-theta, Protein kinase C theta type, PRKCQ
Background: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response.

基因ID

5588

UniProt

Q04759

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling