TET3 抗体 (AA 72-335)
Quick Overview for TET3 抗体 (AA 72-335) (ABIN7159638)
抗原
See all TET3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 72-335
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Methylcytosine dioxygenase TET3 protein (72-335AA)
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亚型
- IgG
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anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 1525-1660) antibody
TET3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 1-937) antibodyTET3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 3 (TET3) (AA 1159-1329) antibodyTET3 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))
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别名
- TET3
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背景
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Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Aliases: hCG_40738 antibody, KIAA0401 antibody, Methylcytosine dioxygenase TET3 antibody, Probable methylcytosine dioxygenase TET3 antibody, Tet methylcytosine dioxygenase 3 antibody, Tet oncogene family member 3 antibody, Tet3 antibody, TET3_HUMAN antibody
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UniProt
- O43151
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途径
- Warburg Effect
抗原
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