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- 抗原 See all EPM2A 抗体
- EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))
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抗原表位
- AA 244-331
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EPM2A antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Laforin protein (244-331AA)
- 亚型
- IgG
- Top Product
- Discover our top product EPM2A Primary Antibody
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anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 101-199) antibody
EPM2A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6C6 unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (C-Term) antibodyEPM2A 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 1-331), (Isoform 9) antibodyEPM2A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) antibodyEPM2A 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 1-331) antibodyEPM2A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 243-331) antibodyEPM2A 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal k2A3 unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 80-130) antibodyEPM2A 适用: 人, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 101-199) antibodyEPM2A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (AA 1-331) antibodyEPM2A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (Internal Region) antibodyVerified EPM2A 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))
- 别名
- EPM2A (EPM2A 产品)
- 别名
- TG-B antibody, Tg(TcraK,TcrbK)TG-BFlv antibody, EPM2 antibody, MELF antibody, laforin antibody, EPM2A, laforin glucan phosphatase antibody, epilepsy, progressive myoclonic epilepsy, type 2 gene alpha antibody, EPM2A antibody, Epm2a antibody
- 背景
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Background: Has both dual-specificity protein phosphatase and glucan phosphatase activities. Together with the E3 ubiquitin ligase NHLRC1/malin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. Dephosphorylates phosphotyrosine, phosphoserine and phosphothreonine substrates in vitro. Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.
Aliases: Epilepsy progressive myoclonus type 2 Lafora disease (laforin) antibody, Epilepsy progressive myoclonus type 2A Lafora disease (laforin) antibody, EPM2 antibody, Epm2a antibody, Epm2a gene antibody, EPM2A_HUMAN antibody, Lafora PTPase antibody, Laforin antibody, LAFPTPase antibody, LD antibody, LDE antibody, MELF antibody, RP3-466P17.2 antibody
- UniProt
- O95278
- 途径
- Cellular Glucan Metabolic Process
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