KSR2 抗体 (AA 159-296) (FITC)
Quick Overview for KSR2 抗体 (AA 159-296) (FITC) (ABIN7157560)
抗原
See all KSR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 159-296
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Kinase suppressor of Ras 2 protein (159-296AA)
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亚型
- IgG
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- KSR2 (Kinase Suppressor of Ras 2 (KSR2))
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别名
- KSR2
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背景
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Background: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Aliases: FLJ25965 antibody, hKSR 2 antibody, hKSR2 antibody, Kinase suppressor of Ras 2 antibody, KSR 2 antibody, Ksr2 antibody, KSR2_HUMAN antibody
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UniProt
- Q6VAB6
抗原
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