IL36A/IL1F6 抗体 (AA 1-158)
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北京 101111
Quick Overview for IL36A/IL1F6 抗体 (AA 1-158) (ABIN7156903)
抗原
See all IL36A/IL1F6 (IL1F6) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-158
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原理
- IL36A Antibody
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Interleukin-36 alpha protein (1-158AA)
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亚型
- IgG
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anti-Interleukin 1 Family, Member 6 (IL1F6) antibody
IL1F6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family, Member 6 (IL1F6) (AA 35-61) antibodyIL1F6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB25982 unconjugated
anti-Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) antibodyIL1F6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family, Member 6 (IL1F6) antibodyIL1F6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) antibodyIL1F6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
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别名
- IL36A
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背景
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Background: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.
Aliases: FIL1 antibody, FIL1 epsilon antibody, FIL1(EPSILON) antibody, FIL1E antibody, IL 1 epsilon antibody, IL 1F6 antibody, IL 1H1 antibody, IL-1 epsilon antibody, IL-1F6 antibody, IL1E antibody, IL1F6 antibody, IL1F6_HUMAN antibody, IL1RP2 antibody, IL36 alpha antibody, IL36A antibody, Interleukin 1 epsilon antibody, Interleukin 1 family member 6 (epsilon) antibody, Interleukin 1 family member 6 antibody, Interleukin 36 alpha antibody, Interleukin-1 epsilon antibody, Interleukin-1 family member 6 antibody, MGC129552 antibody, MGC129553 antibody, MGC151479 antibody, MGC151481 antibody, OTTMUSP00000012798 antibody, RP23-176J12.4 antibody
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UniProt
- Q9UHA7
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途径
- Cancer Immune Checkpoints
抗原
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