IPO13 抗体 (AA 501-700)
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北京 101111
Quick Overview for IPO13 抗体 (AA 501-700) (ABIN7156142)
抗原
See all IPO13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-700
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原理
- IPO13 Antibody
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Importin-13 protein (501-700AA)
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亚型
- IgG
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anti-Importin 13 (IPO13) (C-Term) antibody
IPO13 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Importin 13 (IPO13) antibodyIPO13 适用: 人 ELISA, WB, IHC 宿主: 兔 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- IPO13 (Importin 13 (IPO13))
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别名
- IPO13
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背景
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Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Aliases: Imp 13 antibody, Imp13 antibody, Importin-13 antibody, Importin13 antibody, IPO 13 antibody, Ipo13 antibody, IPO13_HUMAN antibody, Kap 13 antibody, Kap13 antibody, Karyopherin 13 antibody, Karyopherin-13 antibody, Karyopherin13 antibody, KIAA0274 antibody, Late gestation lung 2 antibody, Late gestation lung 2 protein antibody, Lgl2 antibody, Ran binding protein 13 antibody, Ran-binding protein 13 antibody, RanBP 13 antibody, RanBP13 antibody
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UniProt
- O94829
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Protein targeting to Nucleus
抗原
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