HINT1 抗体 (AA 2-126)
Quick Overview for HINT1 抗体 (AA 2-126) (ABIN7155253)
抗原
See all HINT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-126
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Histidine triad nucleotide-binding protein 1 protein (2-126AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))
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别名
- HINT1
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背景
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Background: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5\\\'monophosphoramidate (AMP-NH2), adenosine 5\\\'monophosphomorpholidate (AMP-morpholidate) and guanosine 5\\\'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5\\\'-O-phosphorothioate and guanosine 5\\\'-O-phosphorothioate to the corresponding nucleoside 5\\\'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
Aliases: Adenosine 5' monophosphoramidase antibody, Adenosine 5''-monophosphoramidase antibody, HINT 1 antibody, HINT1 antibody, HINT1_HUMAN antibody, Histidine triad nucleotide binding protein 1 antibody, Histidine triad nucleotide-binding protein 1 antibody, PKCI 1 antibody, PKCI-1 antibody, PKCI1 antibody, PRKCNH1 antibody, Protein kinase C inhibitor 1 antibody, Protein kinase C interacting protein 1 antibody, Protein kinase C-interacting protein 1 antibody
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UniProt
- P49773
抗原
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