PIK3R1 抗体 (AA 15-180)
Quick Overview for PIK3R1 抗体 (AA 15-180) (ABIN7154494)
抗原
See all PIK3R1 (PI3K p85a) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-180
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Growth factor receptor-bound protein 10 protein (15-180AA)
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亚型
- IgG
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anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 1-454) antibody
PI3K p85a 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 3A10 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (pTyr607) antibodyPI3K p85a 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 159-388) antibodyPI3K p85a 适用: 人, 小鼠 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 6G10 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 501-600) antibodyPI3K p85a 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 1-30), (N-Term) antibodyPI3K p85a 适用: 人, 大鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB11634 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 159-388) antibodyPI3K p85a 适用: 人, 小鼠 WB, ELISA, IHC, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) antibodyPI3K p85a 适用: 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 3B7 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 1-424) antibodyPI3K p85a 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (C-Term) antibodyPI3K p85a 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (pTyr368) antibodyPI3K p85a 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
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别名
- GRB1
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背景
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Background: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Aliases: grb 10 antibody, GRB IR antibody, grb-10 antibody, GRB10 adapter protein antibody, GRB10 adaptor protein antibody, GRB10 antibody, GRB10_HUMAN antibody, GRBIR antibody, Growth factor receptor bound protein 10 antibody, Growth factor receptor-bound protein 10 antibody, Insulin receptor binding protein antibody, Insulin receptor binding protein GRB IR antibody, Insulin receptor-binding protein Grb-IR antibody, IRBP antibody, KIAA0207 antibody, Maternally expressed gene 1 antibody, MEG1 antibody, RSS antibody
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UniProt
- Q13322
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途径
- TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect
抗原
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