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Cyclin D2 抗体 (AA 1-289)

This anti-Cyclin D2 antibody is a 兔 多克隆 antibody detecting Cyclin D2 in WB, ELISA, IHC 和 IF. Suitable for 人.
产品编号 ABIN7153389
发货至: 中国

Quick Overview for Cyclin D2 抗体 (AA 1-289) (ABIN7153389)

抗原

See all Cyclin D2 (CCND2) 抗体
Cyclin D2 (CCND2)

适用

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宿主

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克隆类型

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多克隆

标记

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This Cyclin D2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 抗原表位

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    AA 1-289

    交叉反应

    纯化方法

    Antigen Affinity purified

    免疫原

    Recombinant Human G1/S-specific cyclin-D2 protein (1-289AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:500, IF:1:50-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    Cyclin D2 (CCND2)

    别名

    CCND2

    背景

    Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

    Aliases: CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody, MPPH3 antibody

    UniProt

    P30279

    途径

    Cell Division Cycle, Mitotic G1-G1/S Phases
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