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FOXP1 抗体 (AA 541-677) (FITC)

This anti-FOXP1 antibody is a 兔 多克隆 antibody detecting FOXP1 in . Suitable for 人.
产品编号 ABIN7153094
发货至: 中国

Quick Overview for FOXP1 抗体 (AA 541-677) (FITC) (ABIN7153094)

抗原

See all FOXP1 抗体
FOXP1 (Forkhead Box P1 (FOXP1))

适用

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宿主

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克隆类型

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多克隆

标记

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This FOXP1 antibody is conjugated to FITC

应用范围

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  • 抗原表位

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    AA 541-677

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Forkhead box protein P1 protein (541-677AA)

    亚型

    IgG
  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    FOXP1 (Forkhead Box P1 (FOXP1))

    别名

    FOXP1

    背景

    Background: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

    Aliases: 12CC4 antibody, FLJ23741 antibody, Fork head related protein like B antibody, Forkhead box P1 antibody, Forkhead box protein P1 antibody, FOX P1 antibody, FOXP 1 antibody, foxp1 antibody, FOXP1_HUMAN antibody, Glutamine rich factor 1 antibody, hFKH1B antibody, HSPC215 antibody, MGC12942 antibody, MGC88572 antibody, MGC99551 antibody, QRF 1 antibody, QRF1 antibody

    UniProt

    Q9H334

    途径

    Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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