FAN1 抗体 (AA 167-373) (HRP)
Quick Overview for FAN1 抗体 (AA 167-373) (HRP) (ABIN7152569)
抗原
See all FAN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 167-373
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)
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亚型
- IgG
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anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 1-533) antibody
FAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 167-373) antibodyFAN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) antibodyFAN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) (AA 146-174), (N-Term) antibodyFAN1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB26526 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))
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别名
- FAN1
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背景
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Background: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5\'-3\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3\'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3\' flap (PubMed:25430771). Also has endonuclease activity toward 5\'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
Aliases: 6030441H18Rik antibody, Coiled coil domain containing protein MTMR15 antibody, DKFZp451H236 antibody, DKFZp686K16147 antibody, FAN1 antibody, FAN1_HUMAN antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, Fanconi associated nuclease 1 antibody, Fanconi-associated nuclease 1 antibody, hFAN1 antibody, KIAA1018 antibody, KMIN antibody, MTMR 15 antibody, MTMR15 antibody, Myotubularin related protein 15 antibody, Myotubularin-related protein 15 antibody
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UniProt
- Q9Y2M0
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途径
- DNA Damage Repair
抗原
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