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FBXW5 抗体 (AA 265-494) (FITC)

This anti-FBXW5 antibody is a 兔 多克隆 antibody detecting FBXW5 in . Suitable for 人.
产品编号 ABIN7152507
发货至: 中国

Quick Overview for FBXW5 抗体 (AA 265-494) (FITC) (ABIN7152507)

抗原

See all FBXW5 抗体
FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

适用

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宿主

  • 32
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克隆类型

  • 34
多克隆

标记

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This FBXW5 antibody is conjugated to FITC

应用范围

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  • 抗原表位

    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    AA 265-494

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human F-box/WD repeat-containing protein 5 protein (265-494AA)

    亚型

    IgG
  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

    别名

    FBXW5

    背景

    Background: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.

    Aliases: FBXW5 antibody, FBW5 antibody, PP3971F-box/WD repeat-containing protein 5 antibody, F-box and WD-40 domain-containing protein 5 antibody

    UniProt

    Q969U6
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